Hydrazine hydrate (1:1) → 3-(2,4-Dichlorophenyl)-1,9-dimethyl-6-[5-(tetrahydropyran-2-yloxymethyl)-2H-pyrazol-3-yl]-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559192Notes

Reaction equation

HRID 559192 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:35](=[O:36])[N:34]([CH3:37])[C:12]2[N:13]([CH3:33])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20](=O)[CH2:21][C:22](=O)[CH2:23][O:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][O:26]1)=[CH:16][CH:15]=3.O.[NH2:39][NH2:40]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:35](=[O:36])[N:34]([CH3:37])[C:12]2[N:13]([CH3:33])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[NH:39][N:40]=[C:22]([CH2:23][O:24][CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][O:26]2)[CH:21]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 669974671-[3-(2,4-Dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-4-(tetrahydropyran-2-yloxy)butane-1,3-dione

Product 1

HCID 1784813663-(2,4-Dichlorophenyl)-1,9-dimethyl-6-[5-(tetrahydropyran-2-yloxymethyl)-2H-pyrazol-3-yl]-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as in Example 80 above, with compound A, 1-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-4-(tetrahydropyran-2-yloxy)butane-1,3-dione and hydrazine monohydrate.

Sources & evidence

ORD record
ord-3562925d40674fb9b7202830b837826f
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

Loading…