Bromomethylcyclopropane → HCID 66997899, compound

HRID 559226Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:30](=[O:31])[N:29]([CH3:32])[C:12]2[N:13]([CH3:28])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:24]=[CH:23][N:22]([CH2:25][CH2:26][OH:27])[N:21]=1)=[CH:16][CH:15]=3.Br[CH2:34][CH:35]1[CH2:37][CH2:36]1>>[CH:35]1([CH2:34][O:27][CH2:26][CH2:25][N:22]2[CH:23]=[CH:24][C:20]([C:17]3[CH:18]=[C:19]4[C:14](=[CH:15][CH:16]=3)[N:13]([CH3:28])[C:12]3[N:29]([CH3:32])[C:30](=[O:31])[C:9]([C:3]5[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=5[Cl:1])=[CH:10][C:11]4=3)=[N:21]2)[CH2:37][CH2:36]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 66997394HCID 66997394, compound

Product 1

HCID 66997899HCID 66997899, compound

Procedure

The process is carried out as in Example 101 above, with the compound from Example 51, 3-(2,4-dichlorophenyl)-6-[1-(2-hydroxyethyl)-1H-pyrazol-3-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one and (bromomethyl)cyclopropane.

Sources & evidence

ORD record: ord-fc53b5470b3a4094b2f90c1eceb29e1b
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063061B2

Reaction notes

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