2-Hydrazinoethanol → 3-(2,4-Dichlorophenyl)-6-[2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559245Notes

Reaction equation

HRID 559245 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:29](=[O:30])[N:28]([CH3:31])[C:12]2[N:13]([CH3:27])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20](=O)[CH:21]=[CH:22]N(C)C)=[CH:16][CH:15]=3.[OH:32][CH2:33][CH2:34][NH:35][NH2:36]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:29](=[O:30])[N:28]([CH3:31])[C:12]2[N:13]([CH3:27])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[N:35]([CH2:34][CH2:33][OH:32])[N:36]=[CH:22][CH:21]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 80172-HydrazinoethanolHCID 669973133-(2,4-Dichlorophenyl)-6-(3-dimethylaminoacryloyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 669981143-(2,4-Dichlorophenyl)-6-[2-(2-hydroxyethyl)-2H-pyrazol-3-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as in Example 37 above, with the compound from preparation 1.10, 3-(2,4-dichlorophenyl)-6-[3-(dimethylamino)prop-2-enoyl]-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one and 2-hydroxyethylhydrazine

Sources & evidence

ORD record
ord-9116b4180b5e4f44af337ad66cf390f2
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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