Bromomethylcyclopropane → HCID 66998406, compound

HRID 559253Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:29](=[O:30])[N:28]([CH3:31])[C:12]2[N:13]([CH3:27])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[N:21]=[C:22]([CH2:25][OH:26])[S:23][CH:24]=1)=[CH:16][CH:15]=3.Br[CH2:33][CH:34]1[CH2:36][CH2:35]1>>[CH:34]1([CH2:33][O:26][CH2:25][C:22]2[S:23][CH:24]=[C:20]([C:17]3[CH:18]=[C:19]4[C:14](=[CH:15][CH:16]=3)[N:13]([CH3:27])[C:12]3[N:28]([CH3:31])[C:29](=[O:30])[C:9]([C:3]5[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=5[Cl:1])=[CH:10][C:11]4=3)[N:21]=2)[CH2:36][CH2:35]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 66998274HCID 66998274, compound

Product 1

HCID 66998406HCID 66998406, compound

Procedure

The process is carried out as indicated in Example 10 above, with the compound from Example 9, 3-(2,4-dichlorophenyl)-6-(2-hydroxymethylthiazol-4-yl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one, and bromomethylcyclopropane.

Sources & evidence

ORD record: ord-2e57eaca0dea46bc92f5c4579b3011dc
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063061B2

Reaction notes

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