Hydrazine hydrate (1:1) → HCID 178481368, compound

HRID 559266Notes

Reaction equation

HRID 559266 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:31](=[O:32])[N:30]([CH3:33])[C:12]2[N:13]([CH:27]([F:29])[F:28])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20](=O)/[CH:21]=[CH:22]/[N:23](C)C)=[CH:16][CH:15]=3.O.[NH2:35]N>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:31](=[O:32])[N:30]([CH3:33])[C:12]2[N:13]([CH:27]([F:29])[F:28])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:21]=[CH:22][NH:23][N:35]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 669979273-(2,4-dichlorophenyl)-9-difluoromethyl-6-((E)-3-dimethylaminoacryloyl)-1-methyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 178481368HCID 178481368, compound

Procedure

The process is carried out as indicated in Example 40 above, with the compound from Example 151B, 3-(2,4-dichlorophenyl)-9-difluoromethyl-6-((E)-3-dimethylamino-acryloyl)-1-methyl-1,9-dihydropyrido[2,3-b]indol-2-one, and hydrazine monohydrate.

Sources & evidence

ORD record
ord-753386d635a544978d7b072364187ae5
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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