反应详情

温度

100 °C

To a solution of 2-{(S)-1-[(3R,4S)-1-benzyl-4-(4-chloro-3-fluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-5-chloro-pyridine 98 mg (0.22 mmol) dissolved in toluene (5 mL) were added 0.072 mL (0.66 mmol) of 1-chloroethyl chloroformate and 0.11 mL (0.66 mL) of Hunig's base. The reaction mixture was heated at 100° C. for one hour. After cooling down to RT, volatiles were removed under vacuo and the crude was dissolved in MeOH (5 mL). The reaction mixture was heated at 85° C. for 30 minutes and after cooling down to RT, volatiles were removed under vacuo and the residue was directly purified on column chromatography (SiO2, CH2Cl2/MeOH 9:1) yielded 75 mg (95%) of the title compound as a light yellow oil. ES-MS m/e: 355.1 (M+H+).

1. temperatureAfter cooling down to RT
2. customvolatiles were removed under vacuo
3. dissolutionthe crude was dissolved in MeOH (5 mL)
4. temperatureThe reaction mixture was heated at 85° C. for 30 minutes
5. temperatureafter cooling down to RT
6. customvolatiles were removed under vacuo
7. customthe residue was directly purified on column chromatography (SiO2, CH2Cl2/MeOH 9:1)