Ethyl Acetate → Ethylacetate heptane

HRID 55934Notes

Reaction equation

HRID 55934 reaction equation
[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2].[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>>[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2].[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 8900Heptane

Product 1

HCID 21899848Ethylacetate heptaneYield 72%

Conditions

Temperature
75 °C

Procedure

5 g of crude (I) wherein n is 1 were loaded in a reactor together with 30 ml of ethyl acetate and the suspension was stirred while heating to 75° C. until complete dissolution of the solid. 15 ml of n-heptane were added and the solution was allowed to reach RT. The suspension was cooled down to 5° C. for 2 hours, filtered and dried under vacuum. A white solid, the so-called Form A, was obtained (3.6 g, 72% yield).

Workup

  1. customto reach RT
  2. temperatureThe suspension was cooled down to 5° C. for 2 hours
  3. filtrationfiltered
  4. customdried under vacuum
  5. customA white solid, the so-called Form A, was obtained (3.6 g, 72% yield)

Sources & evidence

ORD record
ord-36dc37ef5b9e4ac7b453c0632f4ea3b5
Source dataset
uspto-grants-2016_09
Patent number
US09434691B2

Reaction notes

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