Hydrochloric Acid → HCID 66783501, compound

HRID 559346Notes

Reaction equation

HRID 559346 reaction equation
C([N:8]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][C:10](=[O:15])[CH2:9]1)C1C=CC=CC=1.[ClH:16].[H][H]>CO.[Pd]>[ClH:16].[CH3:14][C@@H:12]1[CH2:13][NH:8][CH2:9][C@@H:10]([OH:15])[CH2:11]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 66782705HCID 66782705, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66783501HCID 66783501, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (S)-1-benzyl-5-methyl-piperidin-3-one (0.9 g, 4 mmol) was dissolved in methanol, 25% aq, hydrochloric acid solution added until the pH was acidic, followed by palladium (10% on activated charcoal, 0.2 g). The mixture was stirred under 1 atmosphere of hydrogen (balloon) for 6 h. The reaction was then filtered through Hyflo and concentrated to afford the title product as a white powder (0.66 g, quant). MS (ISP)=116.1 (M+H)+.

Workup

  1. filtrationThe reaction was then filtered through Hyflo
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-7dbf1eebc1c04a908a1cc800962940d5
Source dataset
uspto-grants-2011_11
Patent number
US08063042B2

Reaction notes

Loading…