HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenethylamine → 2,2-dimethoxy-N-(1-phenylethyl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenethylamine | HCID 7408 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2,2-dimethoxy-N-(1-phenylethyl)ethanamine | HCID 60686999 | — |
Reaction Steps
A solution of α-methylbenzylamine (8.37 g, 0.07 mol) and bromoacetaldehyde dimethylacetal (11.67 g, 0.07 mol) in acetonitrile (150 ml) containing potassium carbonate (12.39 g, 0.09 mol) was heated at reflux for 2d and cooled. The solid was filtered off and the filtrate was concentrated under reduced pressure to leave an oil. Chromatography on silica gel eluting with ethyl acetate afforded the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063078B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-90d77be095904265a7d0f9d7294cb682 |
| Source note | uspto-grants-2011_11 |