Hydrazine → HCID 67001472, compound

HRID 559507Notes

Reaction equation

HRID 559507 reaction equation
[Cl:1][C:2]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8](=O)[CH:9]=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([S:17]([N:20]([CH2:26][O:27][CH3:28])[C:21]2[S:22][CH:23]=[CH:24][N:25]=2)(=[O:19])=[O:18])=[CH:13][CH:12]=1.[NH2:35][NH2:36]>C(O)C>[Cl:1][C:2]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]1[CH2:9][CH:10]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([N:20]([CH2:26][O:27][CH3:28])[C:21]3[S:22][CH:23]=[CH:24][N:25]=3)(=[O:19])=[O:18])=[CH:13][CH:12]=2)[NH:35][N:36]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 67001283HCID 67001283, compound

Product 1

HCID 67001472HCID 67001472, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-[6-(2,4-Dichloro-phenoxy)-3-oxo-hex-1-enyl]-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.259 mmol) and hydrazine (2 mL) was heated to 80° C. in ethanol (15 mL) for 2 h. The solution was concentrated in vacuo. The crude 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-3,4-dihydro-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide was used without further purification.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customThe crude 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-3,4-dihydro-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide was used without further purification

Sources & evidence

ORD record
ord-d44fd7e42c354b669ed50baccc41ba37
Source dataset
uspto-grants-2011_11
Patent number
US08063080B2

Reaction notes

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