HCID 67001472, compound → HCID 178496786, compound

HRID 559508Notes

Reaction equation

HRID 559508 reaction equation
[Cl:1][C:2]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]1[CH2:9][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([N:22]([CH2:28][O:29][CH3:30])[C:23]3[S:24][CH:25]=[CH:26][N:27]=3)(=[O:21])=[O:20])=[CH:15][CH:14]=2)[NH:11][N:12]=1>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[Cl:1][C:2]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[C:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([N:22]([CH2:28][O:29][CH3:30])[C:23]3[S:24][CH:25]=[CH:26][N:27]=3)(=[O:21])=[O:20])=[CH:15][CH:14]=2)[NH:11][N:12]=1

Participants

4

Reactant 1

HCID 67001472HCID 67001472, compound

Product 1

HCID 178496786HCID 178496786, compound

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6212ChloroformSolvent

Procedure

A large excess of manganese oxide was added to 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-3,4-dihydro-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.259 mmol) in chloroform (20 mL). After stirring for 4 h the solution was filtered thorough Celite and concentrated in vacuo. The crude 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide was used without further purification.

Workup

  1. filtrationwas filtered thorough Celite
  2. concentrationconcentrated in vacuo
  3. customThe crude 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide was used without further purification

Sources & evidence

ORD record
ord-a09dff9b8d844f6daf6e10ad4e55990c
Source dataset
uspto-grants-2011_11
Patent number
US08063080B2

Reaction notes

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