Hydrochloric Acid → HCID 178496786, compound

Participants

Reaction Steps

4-{5-[3-(2,4-Dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.259 mmol) and 6 N HCl (1 mL) was heated to 80° C. in ethanol (1 mL) for 3 h. The solution was concentrated in vacuo. The crude material was purified by reverse phase chromatography to yield 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-thiazol-2-yl-benzenesulfonamide (0.041 mmol) and 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.024 mmol) was recovered.

Provenance & Evidence