Hydrochloric Acid → HCID 178496786, compound

HRID 559509Notes

Reaction equation

HRID 559509 reaction equation
[Cl:1][C:2]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[C:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([N:22]([CH2:28][O:29][CH3:30])[C:23]3[S:24][CH:25]=[CH:26][N:27]=3)(=[O:21])=[O:20])=[CH:15][CH:14]=2)[NH:11][N:12]=1.Cl>C(O)C>[Cl:1][C:2]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[C:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([NH:22][C:23]3[S:24][CH:25]=[CH:26][N:27]=3)(=[O:20])=[O:21])=[CH:15][CH:14]=2)[NH:11][N:12]=1.[Cl:1][C:2]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[C:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([N:22]([CH2:28][O:29][CH3:30])[C:23]3[S:24][CH:25]=[CH:26][N:27]=3)(=[O:21])=[O:20])=[CH:15][CH:14]=2)[NH:11][N:12]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178496786HCID 178496786, compound

Product 2

HCID 178496786HCID 178496786, compoundHCID 178527551HCID 178527551, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-{5-[3-(2,4-Dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.259 mmol) and 6 N HCl (1 mL) was heated to 80° C. in ethanol (1 mL) for 3 h. The solution was concentrated in vacuo. The crude material was purified by reverse phase chromatography to yield 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-thiazol-2-yl-benzenesulfonamide (0.041 mmol) and 4-{5-[3-(2,4-dichloro-phenoxy)-propyl]-2H-pyrazol-3-yl}-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.024 mmol) was recovered.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customThe crude material was purified by reverse phase chromatography

Sources & evidence

ORD record
ord-1b939199d52a401288f310814c6f7e88
Source dataset
uspto-grants-2011_11
Patent number
US08063080B2

Reaction notes

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