反应详情

To a stirred solution of 2-chloro-6-methoxy-isonicotinic acid methyl ester (8.5 g, 42 mmol) in DMF (100 mL) was added sodium thiomethoxide (3.22 g, 41.6 mmol), resulting in a yellow colored solution. After 18 hours, the mixture was quenched with saturated aqueous ammonium chloride (100 mL) and extracted with ethyl acetate (4×50 mL). The combined organic layers were washed with brine (50 mL), dried over sodium sulfate and concentrated in vacuo to afford 2-methoxy-6-methylsulfanyl-isonicotinic acid methyl ester.

1. customresulting in a yellow colored solution
2. customthe mixture was quenched with saturated aqueous ammonium chloride (100 mL)
3. extractionextracted with ethyl acetate (4×50 mL)
4. washThe combined organic layers were washed with brine (50 mL)
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo