Diethylamine → HCID 59278268, compound

HRID 559696Notes

Reaction equation

HRID 559696 reaction equation
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:25]([O:27][CH3:28])=[O:26])[C@@H:3]([CH3:24])[O:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(NCC)C>C(#N)C>[NH2:1][C@H:2]([C:25]([O:27][CH3:28])=[O:26])[C@@H:3]([CH3:24])[O:4][C:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 59278391HCID 59278391, compound

Product 1

HCID 59278268HCID 59278268, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of Fmoc-L-Thr(Trt)-OMe (2.40 g, 4.00 mmol) in acetonitrile (20.0 mL) was added diethylamine (20.0 mL). After 30 minutes, the mixture was concentrated in vacuo and the residue was diluted with acetonitrile (3×10 mL) and azeotroped in vacuo to afford L-Thr(Trt)-OMe which was used without further purification.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. additionthe residue was diluted with acetonitrile (3×10 mL)
  3. customazeotroped in vacuo

Sources & evidence

ORD record
ord-48336016342c4666836929334077afea
Source dataset
uspto-grants-2011_11
Patent number
US08063065B2

Reaction notes

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