Hydrochloric Acid → HCID 66727315, compound

HRID 559718Notes

Reaction equation

HRID 559718 reaction equation
[Br:1][C:2]1[CH:6]=[C:5]([C@@H:7]([NH:10]S(C(C)(C)C)=O)[CH2:8][CH3:9])[O:4][N:3]=1.[ClH:17].O1CCOCC1>CO>[ClH:17].[Br:1][C:2]1[CH:6]=[C:5]([C@@H:7]([NH2:10])[CH2:8][CH3:9])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727467HCID 66727467, compound

Product 1

HCID 66727315HCID 66727315, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(3-bromo-isoxazol-5-yl)-propyl]-amide (17.5 mg, 0.0566 mmol) in MeOH (1 mL) was added a 4 M solution of HCl in dioxane (0.70 mL, 0.28 mmol) dropwise. After 2.5 hours, the mixture was concentrated in vacuo to afford the title compound which was used with out purification. MS m/z 188.24 (M−53), 190.20 (M+2−53).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-91e8acd26e004795bab764920ee0802f
Source dataset
uspto-grants-2011_11
Patent number
US08063065B2

Reaction notes

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