Hydrochloric Acid → HCID 66727359, compound

HRID 559755Notes

Reaction equation

HRID 559755 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C@@H:11]([NH:14]S(C(C)(C)C)=O)[CH2:12][CH3:13])[CH:8]=[CH:7][N:6]=1)(=[O:4])=[O:3].[ClH:21].O1CCOCC1>CO>[ClH:21].[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C@@H:11]([NH2:14])[CH2:12][CH3:13])[CH:8]=[CH:7][N:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727370HCID 66727370, compound

Product 1

HCID 66727359HCID 66727359, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(2-methanesulfonyl-pyridin-4-yl)-propyl]-amide (26 g, 82 mmol) in methanol (150 mL) was added a solution of 4 N HCl in dioxane (22.5 ml, 89.8 mmol) and stirred for 1 hour. The solution was concentrated to half the original volume and diluted with toluene (100 mL), and concentrated. The crude material was co-evaporated from toluene (3×100 mL) and dried in vacuo for 18 hours to afford the title compound as an off-white solid.

Workup

  1. concentrationThe solution was concentrated to half the original volume
  2. additiondiluted with toluene (100 mL)
  3. concentrationconcentrated
  4. customdried in vacuo for 18 hours

Sources & evidence

ORD record
ord-eb76390d5a42472d82e63243c452635d
Source dataset
uspto-grants-2011_11
Patent number
US08063065B2

Reaction notes

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