HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (5-(Methylsulfonyl)pyridin-2-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 5-(Methylsulfonyl)pyridine-2-carbonitrile | HCID 59169929 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (5-(Methylsulfonyl)pyridin-2-yl)methanamine | HCID 57354332 | — |
Reaction Steps
A solution of 5-methanesulfonyl-pyridine-2-carbonitrile (120 mg, 0.66 mmol) in methanol was hydrogenated over 10% Pd/C catalyst using a continuous flow hydrogenation apparatus (conditions: flow rate 1 mL/minute, 10 bars, 25° C.). The reaction was monitored by HPLC-MS and TLC (ethyl acetate) indicating the disappearance of starting material. The mixture was concentrated in vacuo and then twice diluted with ether-hexanes and concentrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063065B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-45ddf36cfbf844c5ac8aa7187db094d8 |
| Source note | uspto-grants-2011_11 |