反应详情

A solution of 5-methanesulfonyl-pyridine-2-carbonitrile (120 mg, 0.66 mmol) in methanol was hydrogenated over 10% Pd/C catalyst using a continuous flow hydrogenation apparatus (conditions: flow rate 1 mL/minute, 10 bars, 25° C.). The reaction was monitored by HPLC-MS and TLC (ethyl acetate) indicating the disappearance of starting material. The mixture was concentrated in vacuo and then twice diluted with ether-hexanes and concentrated to afford the title compound.

1. customa continuous flow hydrogenation apparatus (conditions: flow rate 1 mL/minute, 10 bars, 25° C.)
2. concentrationThe mixture was concentrated in vacuo
3. additiontwice diluted with ether-hexanes
4. concentrationconcentrated