Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 559789생성일: 2026년 10월 25일
Toluene → 6-Methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-5-phenyl-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
https://huagongshe.com/reaction/559789
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | 5-Iodo-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoro-methyl)phenyl]1,2-dihydropyridine-3-carboxamide | HCID 11519933 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 6-Methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-5-phenyl-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide | HCID 11444082 | 76.2% |
반응 단계
A mixture of phenylboronic acid (25 mg, 0.20 mmol), 1,1′bis(diphenylphosphino)ferrocenedichloropalladium(II) (4 mg, 0.005 mmol), 5-iodo-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (100 mg 0.17 mmol), toluene (1 ml), ethanol (99%, 0.25 ml) and Na2CO3 (2M, 0.25 ml) was stirred at 80° C. overnight, concentrated and the residue was purified by flash chromatography to give the title compound (70 mg, 76%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08063073B2 |
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| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-81f1eef646744551b9e33901497e0f02 |
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| 출처 메모 | uspto-grants-2011_11 |
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