HCID 59732848, compound → HCID 59732753, compound

HRID 559928Notes

Reaction equation

HRID 559928 reaction equation
C[O:2][C:3](=[O:36])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][C:13]2[N:14]=[C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:23]=3[C:29]([CH:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:30])=[O:20])[S:16][CH:17]=2)[CH:7]=[N:6][CH:5]=1>[Li+].[OH-]>[CH:31]1([C:29]([C:23]2[CH:24]=[C:25]([CH3:28])[CH:26]=[CH:27][C:22]=2[NH:21][C:19](=[O:20])[NH:18][C:15]2[S:16][CH:17]=[C:13]([CH2:12][CH2:11][O:10][C:8]3[CH:7]=[N:6][CH:5]=[C:4]([CH:9]=3)[C:3]([OH:36])=[O:2])[N:14]=2)=[O:30])[CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

3

Reactant 1

HCID 59732848HCID 59732848, compound

Product 1

HCID 59732753HCID 59732753, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3939Lithium HydroxideSolvent

Procedure

5-(2-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}ethoxy)nicotinic acid (23 mg, 95%) was prepared from 5-(2-{2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}ethoxy)nicotinic acid methyl ester (0.025 g, 0.05 mmol) and 2.5M LiOH (20 ul) following the general procedure J.

Sources & evidence

ORD record
ord-7fd6c7cf4e984df3a4a7d94128f9e839
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

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