3-(2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl)-propionic acid ethyl ester → 3-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-propionic acid

HRID 559941Notes

Reaction equation

HRID 559941 reaction equation
C([O:3][C:4](=[O:30])[CH2:5][CH2:6][C:7]1[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=2[C:23]([CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:24])=[O:14])[S:10][CH:11]=1)C>[Li+].[OH-]>[CH:25]1([C:23]([C:17]2[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=2[NH:15][C:13](=[O:14])[NH:12][C:9]2[S:10][CH:11]=[C:7]([CH2:6][CH2:5][C:4]([OH:30])=[O:3])[N:8]=2)=[O:24])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 1

HCID 597330663-(2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl)-propionic acid ethyl ester

Product 1

HCID 597330773-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-propionic acidYield 93.4%

Reagents, catalysts & solvents 1

HCID 3939Lithium HydroxideSolvent

Procedure

3-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-propionic acid (15 mg, 88%) was prepared from 3-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-propionic acid ethyl ester (0.03 g, 0.04 mmol) and 2.5M LiOH (20 μL) following the general procedure J.

Sources & evidence

ORD record
ord-34ba3a26f65f417facf2b5daa91d6979
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

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