Hydrochloric Acid → HCID 59732986, compound

HRID 559943Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][C:9]1[N:13]([CH:14]2[CH2:16][CH2:15]2)[C:12]([S:17][CH2:18][C:19]2[N:20]=[C:21]([NH:24][C:25]([NH:27][C:28]3[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][C:29]=3[C:35]([CH:37]3[CH2:41][CH2:40][CH2:39][CH2:38]3)=[O:36])=[O:26])[S:22][CH:23]=2)=[N:11][N:10]=1)(C)(C)C.Cl>>[NH2:7][CH2:8][C:9]1[N:13]([CH:14]2[CH2:16][CH2:15]2)[C:12]([S:17][CH2:18][C:19]2[N:20]=[C:21]([NH:24][C:25]([NH:27][C:28]3[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][C:29]=3[C:35]([CH:37]3[CH2:38][CH2:39][CH2:40][CH2:41]3)=[O:36])=[O:26])[S:22][CH:23]=2)=[N:11][N:10]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 59732767HCID 59732767, compound

Product 1

HCID 59732986HCID 59732986, compoundYield 99.7%

Procedure

1-[4-(5-Aminomethyl-4-cyclopropyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-thiazol-2-yl]-3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-urea (51 mg, 99%) was prepared from (5-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-ylmethyl sulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-ylmethyl)-carbamic acid tert-butyl ester (61 mg, 0.10 mmol) and hydrochloric acid (4 mL, 4.0 M. in dioxane) following the general deprotection procedure.

Sources & evidence

ORD record: ord-6dd1108cc90446ee8558fc7cedb0d9ff
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063081B2

Reaction notes

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