反应详情

To 5.00 g of 2-bromo-1-(3,5-dichloropyridin-2-yl)-1-propanone in 20 ml of N,N-dimethylformamide, 3.27 g of potassium phthalimide was added, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was mixed with 50 ml of water and extracted with ethyl acetate (50 ml×2), and the resulting organic layers were combined, washed with water (30 ml×1) and dried over saturated aqueous sodium chloride and then anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 2.02 g of the desired crude product as brown crystals. The crystals were used in the next step without further purification.

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate (50 ml×2)
3. washwashed with water (30 ml×1)
4. dry with materialdried over saturated aqueous sodium chloride
5. customanhydrous sodium sulfate, and the solvent was evaporated under reduced pressure