2-Aminothiazole → HCID 59733056, compound

HRID 559980Notes

Reaction equation

HRID 559980 reaction equation
NC1C=C(F)C=CC=1[C:4](O)=[O:5].[NH2:12][C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])=[O:21].[NH2:30][C:31]1[S:32][CH:33]=[CH:34][N:35]=1>>[NH2:12][C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])=[O:21].[F:19][C:17]1[CH:16]=[CH:15][C:14]([C:20](=[O:21])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])=[C:13]([NH:12][C:4]([NH:30][C:31]2[S:32][CH:33]=[CH:34][N:35]=2)=[O:5])[CH:18]=1

Participants

5

Reactant 3

HCID 21552-AminothiazoleHCID 27249674-Fluoroanthranilic acidHCID 66998811HCID 66998811, compound

Product 2

HCID 59733056HCID 59733056, compoundYield 68%HCID 66998811HCID 66998811, compoundYield 32%

Procedure

(2-Amino-4-fluoro-phenyl)-(2-methoxy-phenyl)-methanone (784 mg, 32%) was prepared from 2-amino-4-fluoro-benzoic acid (1.55 g, 0.1 mol) following the general procedure S. 1-[5-Fluoro-2-(2-methoxy-benzoyl)-phenyl]-3-thiazol-2-yl-urea (127 mg, 68%) was prepared from (2-amino-4-fluoro-phenyl)-(2-methoxy-phenyl)-methanone (123 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

Sources & evidence

ORD record
ord-0d2d0566310e4fae81f72170ab56cef3
Source dataset
uspto-grants-2011_11
Patent number
US08063081B2

Reaction notes

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