2-Methoxyethylamine → HCID 59732867, compound

HRID 559987Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:21](=[O:30])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])=[C:6]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14]([CH2:16][C:17](O)=[O:18])[N:15]=2)[CH:7]=1.[O:31]([CH2:33][CH2:34][NH2:35])[CH3:32]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:21](=[O:30])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])=[C:6]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:35][CH2:34][CH2:33][O:31][CH3:32])=[O:18])[N:15]=2)[CH:7]=1

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 59732813HCID 59732813, compound

Product 1

HCID 59732867HCID 59732867, compoundYield 65%

Procedure

2-(2-{3-[5-Fluoro-2-(2-methoxy-benzoyl)-phenyl]-ureido}-thiazol-4-yl)-N-(2-methoxy-ethyl)-acetamide (158 mg, 65%) was prepared from (2-{3-[5-fluoro-2-(2-methoxy-benzoyl)-phenyl]-ureido}-thiazol-4-yl)-acetic acid (215 mg, 0.5 mmol) and 2-methoxylethylamine (38 mg, 0.5 mmol) following the general procedure K.

Sources & evidence

ORD record: ord-ced96faa84cd4e83a019ad37956f4e4a
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063081B2

Reaction notes

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