反应详情

In analogy to example 1, step 3, 1-benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one (example 5, step 2) was reacted with (3-methylsulfonylphenyl)boronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(3′-methanesulfonyl-biphenyl-3-yl)-3-phenyl-imidazolidin-2-one as an off-white solid. MS: 533.1 ([M+H]+)