HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 1-Benzenesulfonyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-3-phenyl-imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(Methylsulfonyl)phenylboronic acid | HCID 2773542 | — |
| Reactant | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one | HCID 67001148 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 1-Benzenesulfonyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-3-phenyl-imidazolidin-2-one | HCID 44547741 | — |
Reaction Steps
In analogy to example 1, step 3, 1-benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one (example 5, step 2) was reacted with (3-methylsulfonylphenyl)boronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(3′-methanesulfonyl-biphenyl-3-yl)-3-phenyl-imidazolidin-2-one as an off-white solid. MS: 533.1 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063088B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0ca9e8927a17439ea5212ec7d7255ed9 |
| Source note | uspto-grants-2011_11 |