反应详情

1-Benzenesulfonyl-3-isopropyl-4-(3′-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one (example 12, step 2, 1.386 g) and magnesium (0.541 g) were suspended in methanol (30 mL). The mixture was heated to reflux for 4 h and subsequently filtered. The filtrate was concentrated and the product was purified by column chromatography (SiO2, cyclohexane/ethyl acetate 7:3=>0:1) to give 1-isopropyl-5-(3′-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one (0.293 g) as a colorless solid. MS: 359.1 ([M+H]+)

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 h
3. filtrationsubsequently filtered
4. concentrationThe filtrate was concentrated
5. customthe product was purified by column chromatography (SiO2, cyclohexane/ethyl acetate 7:3=>0:1)