反应详情

In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with (2-chloro-5-cyanophenyl)boronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-6-chloro-biphenyl-3-carbonitrile as a light yellow oil. MS: 480.0 ([M+H]+)