HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-6-chloro-biphenyl-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Chloro-5-cyanophenylboronic acid | HCID 2763279 | — |
| Reactant | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-6-chloro-biphenyl-3-carbonitrile | HCID 44548391 | — |
Reaction Steps
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with (2-chloro-5-cyanophenyl)boronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-6-chloro-biphenyl-3-carbonitrile as a light yellow oil. MS: 480.0 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063088B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-1143916cbd8544ba89c1be4bbb557fca |
| Source note | uspto-grants-2011_11 |