HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid tert-butylamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 3-(tert-Butylaminosulphonyl)benzeneboronic acid | HCID 44119538 | — |
| Edukt | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid tert-butylamide | HCID 44548392 | — |
Reaktionsschritte
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 3-tert-butylsulfamoyl-benzeneboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid tert-butylamide as an off-white oil. MS: 572.8 ([M+NH4]+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063088B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-5661b6af02fc4448ab3dd55e847e86b3 |
| Quellennotiz | uspto-grants-2011_11 |