Hydrochloric Acid → 2-amino-1-(3,5-dichloropyridin-2-yl)ethanone-O-(2,2,2-trifluoroethyl)oxime hydrochloride
Reaction equation
[Cl:1][C:2]1[C:3]([C:9](=[N:19][O:20][CH2:21][C:22]([F:25])([F:24])[F:23])[CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl>O1CCOCC1>[ClH:1].[F:24][C:22]([F:23])([F:25])[CH2:21][O:20][N:19]=[C:9]([C:3]1[C:2]([Cl:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=1)[CH2:10][NH2:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 4.9 g of tert-butyl N-[2-(3,5-dichloropyridin-2-yl)-2-(2,2,2-trifluoroethoxyimino)ethyl]carbamate in 5 ml of 1,4-dioxane, 25 ml of a 1,4-dioxane solution (4 mol/L) of hydrogen chloride was added, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was washed with 20 ml of hexane to obtain 3.1 g of the desired product as pale brown crystals.
Workup
- customAfter completion of the reaction
- customthe solvent was evaporated under reduced pressure
- washthe resulting residue was washed with 20 ml of hexane
Sources & evidence
- ORD record
- ord-abdb33470bdd49de8221cdf14f04e272
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434684B2
Reaction notes
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