Piperidine → 1-Piperidin-1-yl-cyclobutanecarbonitrile

HRID 560201Notes

Reaction equation

[N:1]1([C:6]2([C:10]#N)COC2)[CH2:5][CH2:4][CH2:3]C1.[C:12]1(=O)[CH2:15][CH2:14][CH2:13]1.[NH:17]1CCCC[CH2:18]1>>[N:1]1([C:12]2([C:18]#[N:17])[CH2:15][CH2:14][CH2:13]2)[CH2:5][CH2:4][CH2:3][CH2:10][CH2:6]1

Participants

Reactant 3

HCID 8082Piperidine

HCID 14496Cyclobutanone

HCID 591979193-Cyano-3-(pyrrolidin-1-YL)oxetane

Product 1

HCID 438028681-Piperidin-1-yl-cyclobutanecarbonitrile

Procedure

The title compound, light yellow liquid, MS: m/e=165.2 [(M+H)+], was prepared in accordance with the general method of intermediate A from cyclobutanone and piperidine.

Sources & evidence

ORD record: ord-6a8d3d534c02473c9fffb801a2698a84
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063098B2

Reaction notes

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