Thioacetamide → 2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid methyl ester

HRID 560222Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:7]=[C:8]([CH3:12])[CH:9]=[CH:10][CH:11]=1.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:6]1[CH:7]=[C:8]([CH3:12])[CH:9]=[CH:10][CH:11]=1)=[O:15]

Participants

Reactant 2

HCID 2723949Thioacetamide

HCID 53769729HCID 53769729, compound

Product 1

HCID 532711842-Methyl-5-m-tolyl-thiazole-4-carboxylic acid methyl ester

Procedure

prepared by reaction of 3-chloro-2-oxo-3-m-tolyl-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.94 min; [M+H]+=248.0.

Sources & evidence

ORD record: ord-c3228f552f19423a820b0dec731675a3
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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