Thioacetamide → 5-(3-Bromo-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

HRID 560232Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)Cl.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)=[O:15]

Participants

Reactant 2

HCID 2723949Thioacetamide

HCID 64897447HCID 64897447, compound

Product 1

HCID 532712075-(3-Bromo-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

Procedure

prepared by reaction of 3-(3-bromo-phenyl)-3-chloro-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=1.00 min; [M+H]+=312.0.

Sources & evidence

ORD record: ord-264ed30a1b1f41de9974ab97e5cd0b2a
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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