Thioacetamide → 5-(4-Cyano-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

HRID 560234Notes

Reaction equation

HRID 560234 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1.[C:17]([NH2:20])(=[S:19])[CH3:18]>>[CH3:1][O:2][C:3]([C:4]1[N:20]=[C:17]([CH3:18])[S:19][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1)=[O:16]

Participants

3

Reactant 2

HCID 2723949ThioacetamideHCID 866442013-Chloro-3-(4-cyano-phenyl)-2-oxo-propionic acid methyl ester

Product 1

HCID 669986145-(4-Cyano-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

Procedure

prepared by reaction of 3-chloro-3-(4-cyano-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.92 min; [M+H]+=259.0.

Sources & evidence

ORD record
ord-266a1a88b72b49fbb940a45ac38b0467
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

Loading…