Thioacetamide → 5-(2,3-Dimethyl-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

HRID 560236Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:16])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:7]=1[CH3:13].[C:17]([NH2:20])(=[S:19])[CH3:18]>>[CH3:1][O:2][C:3]([C:4]1[N:20]=[C:17]([CH3:18])[S:19][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:7]=1[CH3:13])=[O:16]

Participants

Reactant 2

HCID 2723949Thioacetamide

HCID 64897867HCID 64897867, compound

Product 1

HCID 669987205-(2,3-Dimethyl-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

Procedure

prepared by reaction of 3-chloro-3-(2,3-dimethyl-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.95 min; [M+H]+=262.3.

Sources & evidence

ORD record: ord-273a377e4d9c45dea1a824fa6f09b86f
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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