Thioacetamide → 2-Methyl-5-(3-nitrophenyl)thiazole-4-carboxylic acid methyl ester

HRID 560246Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:17])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1.[C:18]([NH2:21])(=[S:20])[CH3:19]>>[CH3:1][O:2][C:3]([C:4]1[N:21]=[C:18]([CH3:19])[S:20][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)=[O:17]

Participants

Reactant 2

HCID 2723949Thioacetamide

HCID 12193327Methyl 3-(3-nitrophenyl)-3-chloro-2-oxopropionate

Product 1

HCID 668446302-Methyl-5-(3-nitrophenyl)thiazole-4-carboxylic acid methyl ester

Procedure

prepared by reaction of 3-chloro-3-(3-nitro-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.94 min; [M+H]+=279.3.

Sources & evidence

ORD record: ord-75b6937923954d5d885b9fed115290bf
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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