Cyclopropanecarbothioamide → 2-Cyclopropyl-5-(3-fluoro-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

HRID 560250Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1.[CH:16]1([C:19](=[S:21])[NH2:20])[CH2:18][CH2:17]1>>[CH3:1][O:2][C:3]([C:4]1[N:20]=[C:19]([CH:16]2[CH2:18][CH2:17]2)[S:21][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)=[O:15]

Participants

Reactant 2

HCID 22140884Cyclopropanecarbothioamide

HCID 57437155Methyl 3-chloro-3-(3-fluorophenyl)-2-oxopropanoate

Product 1

HCID 668666702-Cyclopropyl-5-(3-fluoro-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

Procedure

prepared by reaction of 3-chloro-3-(3-fluoro-phenyl)-2-oxo-propionic acid methyl ester with cyclopropanecarbothioic acid amide.

Sources & evidence

ORD record: ord-4f04746d807d4fec974d64fecc992f78
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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