Cyclopropanecarbothioamide → 2-Cyclopropyl-5-(3-fluoro-4-methyl-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

HRID 560251Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:16])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([F:13])[CH:7]=1.[CH:17]1([C:20](=[S:22])[NH2:21])[CH2:19][CH2:18]1>>[CH3:1][O:2][C:3]([C:4]1[N:21]=[C:20]([CH:17]2[CH2:19][CH2:18]2)[S:22][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([F:13])[CH:7]=1)=[O:16]

Participants

Reactant 2

HCID 22140884Cyclopropanecarbothioamide

HCID 648982873-Chloro-3-(3-fluoro-4-methyl-phenyl)-2-oxo-propionic acid methyl ester

Product 1

HCID 668656622-Cyclopropyl-5-(3-fluoro-4-methyl-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

Procedure

prepared by reaction of 3-chloro-3-(3-fluoro-4-methyl-phenyl)-2-oxo-propionic acid methyl ester with cyclopropanecarbothioic acid amide.

Sources & evidence

ORD record: ord-2860d0ba78b647c19bf8f27ba25115a1
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

Loading…