Thiourea → Methyl 2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylate

HRID 560253Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1.[NH2:16][C:17]([NH2:19])=[S:18]>>[CH3:1][O:2][C:3]([C:4]1[N:16]=[C:17]([NH2:19])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)=[O:15]

Participants

Reactant 2

HCID 2723790Thiourea

HCID 57437155Methyl 3-chloro-3-(3-fluorophenyl)-2-oxopropanoate

Product 1

HCID 2783208Methyl 2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylate

Procedure

prepared by reaction of 3-chloro-3-(3-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thiourea. LC-MS: tR=0.78 min; [M+H]+=252.9.

Sources & evidence

ORD record: ord-b9726f3b8a294c6d97c510768221a605
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063099B2

Reaction notes

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