6-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acid → (1S,2S,5R)-2-{[(6-Methyl-imidazo[2,1-b]thiazole-5-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid tert-butyl Ester

HRID 560340Notes

Reaction equation

HRID 560340 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][C:17]1[N:18]=[C:19]2[N:23]([C:24]=1[C:25](O)=[O:26])[CH:22]=[CH:21][S:20]2>>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH:15][C:25]([C:24]1[N:23]2[C:19]([S:20][CH:21]=[CH:22]2)=[N:18][C:17]=1[CH3:16])=[O:26])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 3299796-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acidHCID 59444330tert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo(3.1.0)hexane-3-carboxylate

Product 1

HCID 66998725(1S,2S,5R)-2-{[(6-Methyl-imidazo[2,1-b]thiazole-5-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid tert-butyl Ester

Procedure

prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid (A. Andreani et al. Eur. J. Med. Chem. 1982, 17, 271-274).

Sources & evidence

ORD record
ord-a3daaa9696c04cc29c9813efcdd5fc64
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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