HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acid → (1S,2S,5R)-2-{[(6-Methyl-imidazo[2,1-b]thiazole-5-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acid | HCID 329979 | — |
| Reactant | tert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo(3.1.0)hexane-3-carboxylate | HCID 59444330 | — |
| Product | (1S,2S,5R)-2-{[(6-Methyl-imidazo[2,1-b]thiazole-5-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid tert-butyl Ester | HCID 66998725 | — |
Reaction Steps
prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid (A. Andreani et al. Eur. J. Med. Chem. 1982, 17, 271-274).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063099B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-a3daaa9696c04cc29c9813efcdd5fc64 |
| Source note | uspto-grants-2011_11 |