3-Chlorobenzoic Acid → (1S,2S,5R)-2-[(3-Chloro-benzoylamino)-methyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

HRID 560341Notes

Reaction equation

HRID 560341 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20](O)=[O:21]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH:15][C:20](=[O:21])[C:19]1[CH:23]=[CH:24][CH:25]=[C:17]([Cl:16])[CH:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 4473-Chlorobenzoic AcidHCID 59444330tert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo(3.1.0)hexane-3-carboxylate

Product 1

HCID 66998756(1S,2S,5R)-2-[(3-Chloro-benzoylamino)-methyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

Procedure

prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with 3-Chloro-benzoic acid.

Sources & evidence

ORD record
ord-0153099cbc29467eab87b029257c4fdf
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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