2-(Trifluoromethyl)benzoic acid → Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(2-trifluoromethyl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

HRID 560355Notes

Reaction equation

HRID 560355 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10].[F:20][C:21]([F:32])([F:31])[C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](O)=[O:25]>>[F:20][C:21]([F:31])([F:32])[C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24]([N:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C@H:2]1[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10])=[O:25]

Participants

3

Reactant 2

HCID 98992-(Trifluoromethyl)benzoic acidHCID 66998521Benzofuran-4-carboxylic acid[(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 66998359Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(2-trifluoromethyl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Procedure

prepared by reaction of benzofuran-4-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 2-trifluoromethyl-benzoic acid.

Sources & evidence

ORD record
ord-118e39e8fc934a7693344c4a8ab2df60
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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