3-(Trifluoromethyl)benzoic acid → Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(3-trifluoromethyl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

HRID 560357Notes

Reaction equation

HRID 560357 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10].[F:20][C:21]([F:32])([F:31])[C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](O)=[O:26]>>[F:20][C:21]([F:31])([F:32])[C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([N:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C@H:2]1[CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[O:19][CH:18]=[CH:17][C:16]=12)=[O:10])=[O:26]

Participants

3

Reactant 2

HCID 99633-(Trifluoromethyl)benzoic acidHCID 66998521Benzofuran-4-carboxylic acid[(1s,2s,5r)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide

Product 1

HCID 66998826Benzofuran-4-carboxylic acid[(1s,2s,5r)-3-(3-trifluoromethyl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Procedure

prepared by reaction of benzofuran-4-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 3-trifluoromethyl-benzoic acid.

Sources & evidence

ORD record
ord-2cdf75efa5214c80bff0a16941a0ee1f
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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