反应详情

To a solution of 1-(bromomethyl)-2-fluoro-4-nitrobenzene (3.04 g, 13 mmol) in CH2Cl2 (50 mL) were added morpholine (1.74 g, 20 mmol) and Et3N (2.63 g, 26 mmol). The reaction was refluxed overnight, and then concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as a yellow solid (2.05 g, 65%).

1. temperatureThe reaction was refluxed overnight
2. concentrationconcentrated in vacuo
3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)