Hydrochloric Acid → HCID 66680818, compound

HRID 560925Notes

Reaction equation

HRID 560925 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]2[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]C)=[O:19])=[CH:13][CH:12]=2)[NH:4][N:3]=1.Cl>CO>[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]2[CH:16]=[CH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[CH:13][CH:12]=2)[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11219755HCID 11219755, compound

Product 1

HCID 66680818HCID 66680818, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Example 53A (140 mg) in 1:1 methanol/10% NaOH (1 mL) was stirred at room temperature for 2 hours and adjusted to pH 3 with 10% HCl. The resulting precipitate was collected by filtration to provide 108 mg of the desired product. MS (ESI(+)) m/e 268 (M+H)+.

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-e90c4b9dca7944df8b35c0a62008d9f2
Source dataset
uspto-grants-2011_11
Patent number
US08063091B2

Reaction notes

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