反应详情

Add 1 N HCl (5 mL) to a solution of 2-fluoro-4-iodo-5-(1-methoxymethoxy-ethyl)-pyridine (1 g, 3.2 mmol) in methanol (10 mL). Stir the mixture overnight. Dilute the reaction mixture with 2 N sodium carbonate. Abstract the product into chloroform. Dry the organic phase over sodium sulfate. Concentrate the solution in vacuo to a give the crude. Purify the crude by column chromatography (10% methanol in dichloromethane) to afford the product as a white solid (0.75 g, 87%). MS (ES) m/z 268 [M+1]+.

1. dry with materialDry the organic phase over sodium sulfate
2. concentrationConcentrate the solution in vacuo to
3. customa give the crude
4. customPurify the crude by column chromatography (10% methanol in dichloromethane)